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True or False: Antisense oligonucleotides (ASOs) can modulate gene expression by binding to target RNA and triggering degradation or splicing modification.
- True
- False
Answer: True
ASOs are short synthetic nucleic acids designed to hybridize with specific RNA sequences. Approved drugs: Nusinersen (spinal muscular atrophy), Eteplirsen (Duchenne muscular dystrophy). Emerging modality for undruggable targets. [[ICMR Reports, NCERT Biology Class 12]]